Description

Pht-Phe-Met-Otbu CAS NO 89137-47-3 is a protected tripeptide derivative, specifically N-Phthaloyl-L-phenylalanyl-L-methionine tert-butyl ester, serving as a crucial building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring high-purity, structurally defined intermediates for the development of novel peptides and bioactive molecules. It is primarily utilized in pharmaceutical R&D, particularly in the synthesis of complex peptide-based drug candidates and for exploring structure-activity relationships.

Application

• Pharmaceutical Intermediate: A key building block in the solid-phase and solution-phase synthesis of complex peptide-based active pharmaceutical ingredients (APIs).
• Protease Inhibitor Research: Used in the development and study of protease inhibitors due to the presence of methionine and phenylalanine residues.
• Bioconjugation & Labeling: Serves as a precursor for creating labeled peptides or peptide conjugates for diagnostic and research applications.
• Chemical Biology Probes: Employed in the synthesis of specialized peptides used as probes to study enzyme mechanisms and protein-protein interactions.
• Academic & Industrial R&D: A valuable reagent for synthetic chemistry research in universities and corporate laboratories focusing on peptide methodology.
• Custom Peptide Synthesis: Used by contract research and manufacturing organizations (CRMOs) for the production of custom, non-standard peptide sequences for clients.

Basic Information

Product Name	Pht-Phe-Met-Otbu
CAS No.	89137-47-3
Molecular Formula	C27H32N2O5S
Molecular Weight	496.62 g/mol
Synonyms	N-Phthaloyl-L-phenylalanyl-L-methionine tert-butyl ester; N-Phthaloyl-L-Phe-L-Met-OtBu; Phthaloylphenylalanylmethionine tert-butyl ester; Boc-Met(OtBu)-Phe-Phth; Fmoc-Phe-Met(OtBu)-OH (related); L-Phenylalanyl-N-phthaloyl-L-methionine tert-butyl ester; N-(tert-Butoxycarbonyl)-L-methionyl-L-phenylalanine phthalimide; 89137-47-3
EINECS	Contact for details

Quality Control

Our Pht-Phe-Met-Otbu is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and identity confirmation via IR and NMR spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.