Description

Formylmethionyl-α-Aminoisobutyryl-Phenylalanine is a specialized synthetic peptide building block of significant interest in advanced pharmaceutical research and development. This compound serves as a crucial intermediate for the synthesis of novel peptide-based therapeutics and biochemical probes. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing enzyme inhibitors and studying protein-protein interactions. The precise structure allows for the introduction of specific conformational constraints into peptide sequences.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of constrained peptide drugs targeting various disease pathways.
• Protease Inhibitor Development: Used in research to create and test novel inhibitors for specific proteolytic enzymes.
• Biochemical Research: Serves as a standard or reference compound in studies of peptide structure-activity relationships (SAR).
• Peptide Library Synthesis: Employed in combinatorial chemistry to generate diverse peptide libraries for high-throughput screening.
• Conformational Studies: The α-Aminoisobutyryl (Aib) residue induces specific helical structures, making it valuable for studying peptide folding and stability.

Basic Information

Product Name	Formylmethionyl-α-Aminoisobutyryl-Phenylalanine
CAS No.	89026-15-3
Molecular Formula	C20H27N3O5S
Molecular Weight	421.51 g/mol
Synonyms	Fmoc-Aib-Phe-OH (common precursor/related); N-Formyl-Met-Aib-Phe; For-Met-Aib-Phe-OH; Formylmethionyl-2-aminoisobutyryl-phenylalanine; (S)-2-((S)-2-((S)-2-Formamido-4-(methylthio)butanamido)-2-methylpropanamido)-3-phenylpropanoic acid; Aib-containing tripeptide; Constrained peptide intermediate; N-Formyl-L-methionyl-α-aminoisobutyryl-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Formylmethionyl-α-Aminoisobutyryl-Phenylalanine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for fine chemical and pharmaceutical intermediates, ensuring reliable performance in sensitive synthetic workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.