Description

F-Met-Cycl-Leu-Phe CAS NO 89026-13-1 is a specialized cyclic peptide derivative, specifically a modified tetrapeptide containing a fluorinated methionine residue. This compound is a critical building block and research tool in advanced pharmaceutical development, particularly for studying protease specificity and designing novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptide-based drug discovery, chemical biology, and medicinal chemistry programs.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis of novel peptide therapeutics and enzyme inhibitors.
• Protease & Enzyme Studies: Used as a fluorinated substrate or inhibitor to investigate enzyme kinetics, specificity, and catalytic mechanisms.
• Medicinal Chemistry: Acts as a core scaffold for structure-activity relationship (SAR) studies to optimize pharmacokinetic properties and biological activity.
• Chemical Biology Probes: Employed in the development of activity-based probes (ABPs) for labeling and profiling specific enzyme families in complex biological systems.
• Peptide Library Synthesis: Incorporated into combinatorial peptide libraries for high-throughput screening against biological targets.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis, peptide chemistry, and bioorganic chemistry.

Basic Information

Product Name	F-Met-Cycl-Leu-Phe
CAS No.	89026-13-1
Molecular Formula	C26H38FN3O5
Molecular Weight	491.60 g/mol
Synonyms	N-Formyl-L-methionyl-L-leucyl-L-phenylalanine; N-Formyl-Met-Leu-Phe; fMLF; fMLP; Formyl-Met-Leu-Phe; Formylmethionylleucylphenylalanine; Chemotactic peptide fMLF; Cyclo(FLMF)
EINECS	Contact for details

Quality Control

Every batch of F-Met-Cycl-Leu-Phe is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC for purity and identity confirmation via mass spectrometry and NMR, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.