Description

H-D-Me-Val-Oh CAS NO 88930-14-7 is a non-natural, chiral amino acid derivative, specifically the D-enantiomer of N-methylvaline. This compound is a critical building block in modern pharmaceutical synthesis, enabling the creation of complex molecules with precise stereochemistry. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of peptide-based therapeutics, active pharmaceutical ingredients (APIs), and advanced diagnostic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel peptide drugs and protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate N-methylated amino acids, enhancing metabolic stability and bioavailability of therapeutic peptides.
• API Development: Serves as a crucial component in the research and production of Active Pharmaceutical Ingredients (APIs) requiring specific stereochemical configurations.
• Bioconjugation: Employed in the design of peptide-drug conjugates (PDCs) and other targeted delivery systems.
• Chemical Biology Research: Utilized as a tool compound to study enzyme-substrate interactions and to create peptide libraries for screening.
• Catalyst Ligand Synthesis: Can be used in the preparation of chiral ligands for asymmetric catalysis.

Basic Information

Product Name	H-D-Me-Val-Oh
CAS No.	88930-14-7
Molecular Formula	C6H13NO2
Molecular Weight	131.17 g/mol
Synonyms	D-N-Methylvaline; (R)-2-Amino-3-methyl-N-methylbutanoic acid; (R)-N-Methylvaline; D-N-Methylvaline; H-D-Me-Val-OH; D-MeVal-OH; (2R)-2-Amino-3-methyl-N-methylbutanoic acid; D-2-Amino-3-methyl-N-methylbutyric acid
EINECS	Contact for details

Quality Control

Our H-D-Me-Val-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.