Description

Cyclo(Prolyl-Valyl-Prolyl-Valyl) CAS NO 88927-74-6 is a synthetic cyclic tetrapeptide composed of alternating proline and valine amino acid residues. This specific structural motif is of significant interest in pharmaceutical research for its potential to modulate biological pathways and serve as a scaffold for drug discovery. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, peptide-based diagnostics, and biochemical tools.

Application

• Pharmaceutical Research & Development: As a key intermediate or reference standard in the discovery of new bioactive peptides and peptidomimetics.
• Biochemical Studies: Investigation of peptide conformation, stability, and structure-activity relationships (SAR) due to its constrained cyclic structure.
• Protease Inhibitor Scaffold: Exploration of its potential as a core structure for designing inhibitors of specific enzymes.
• Cell Signaling Research: Used in studies targeting intracellular signaling pathways where cyclic peptides act as modulators.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Material Science: Potential building block for advanced biomaterials and nanocarriers in drug delivery systems.

Basic Information

Product Name	Cyclo(Prolyl-Valyl-Prolyl-Valyl)
CAS No.	88927-74-6
Molecular Formula	C22H34N4O4
Molecular Weight	418.53 g/mol
Synonyms	Cyclo(-Pro-Val-Pro-Val-); c(PVPV); Cyclo(Pro-Val-Pro-Val); Cyclic(Pro-Val-Pro-Val) Tetrapeptide; Cyclo(L-Prolyl-L-valyl-L-prolyl-L-valyl); L-Valyl-L-prolyl-L-valyl-L-prolyl cyclic peptide; 1,4-Diaza-2,5-dioxocyclooctane-3,6-dipropanoic acid, 1,4-bis(1-methylethyl)-, (3S,6S)-; Cyclic Pro-Val-Pro-Val
EINECS	Contact for details

Quality Control

Our Cyclo(Prolyl-Valyl-Prolyl-Valyl) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral purity checks, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) providing batch-specific data is available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain purity and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.