Description

Atrial Natriuretic Factor (1-28) (Rat) is a synthetic peptide fragment corresponding to the biologically active sequence of the rat atrial natriuretic peptide (ANP) hormone. This compound is a critical research tool for studying cardiovascular physiology, renal function, and the mechanisms of blood pressure regulation. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in metabolic and cardiovascular disease research, drug discovery, and biochemical assay development.

Application

• Cardiovascular Research: Used as a standard or agonist in studies investigating ANP receptor (NPR-A) signaling, vasodilation, and blood pressure homeostasis.
• Renal Physiology Studies: Essential for research on natriuresis, diuresis, and the regulation of sodium and water balance by the kidneys.
• Biochemical Assay Development: Serves as a reference standard in ELISA, RIA, and other immunoassays designed to detect and quantify ANP levels.
• Cell Signaling & Pharmacology: Applied in in vitro cell-based assays to study cyclic GMP (cGMP) pathway activation and receptor binding kinetics.
• Drug Discovery Screening: Used in high-throughput screening (HTS) platforms to identify novel modulators of the natriuretic peptide system for therapeutic intervention.
• Academic & Educational Use: A key reagent for teaching and advanced research in endocrinology and peptide hormone action.

Basic Information

Product Name	Atrial Natriuretic Factor (1-28) (Rat)
CAS No.	88898-17-3
Molecular Formula	C128H204N40O39S2
Molecular Weight	3081.4 g/mol
Synonyms	Rat ANP (1-28); Atriopeptin (1-28) (rat); Cardionatrin (1-28) (rat); rANP (1-28); Atrial Natriuretic Peptide (1-28), rat; H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide bridge: Cys7-Cys23); ANF (1-28) (rat)
EINECS	Contact for details

Quality Control

Our Atrial Natriuretic Factor (1-28) (Rat) is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and Mass Spectrometry for identity confirmation, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Solubility	Soluble in water or aqueous acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.