Description

Angiotensin II, Sar(1)-Me-Tyr(4)- is a potent, synthetic peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, specifically modified at the 1 and 4 positions to enhance its stability and receptor-binding profile. This compound is a critical research tool for studying the renin-angiotensin system (RAS), which is central to cardiovascular physiology and pathology. It is essential for pharmaceutical R&D, biochemical research, and the development of novel therapeutics targeting hypertension, heart failure, and related disorders.

Application

• Biochemical Research: Used as a reference standard and active ligand in studies of Angiotensin II receptor (AT1 and AT2) signaling, function, and regulation.
• Pharmaceutical Development: Serves as a key intermediate or pharmacological tool in the discovery and screening of new cardiovascular drugs, including receptor antagonists.
• In Vitro Assays: Employed in cell-based assays and tissue bath experiments to investigate vascular contraction, blood pressure mechanisms, and cardiac function.
• Metabolic Studies: Facilitates research into the role of the RAS in metabolic syndromes, kidney function, and fluid-electrolyte balance.
• Academic Research: A fundamental reagent for university and institutional labs focused on endocrinology, physiology, and peptide hormone action.
• Diagnostic Kit Manufacturing: May be utilized in the production of calibration standards for diagnostic assays measuring components of the renin-angiotensin pathway.

Basic Information

Product Name	Angiotensin II, Sar(1)-Me-Tyr(4)-
CAS No.	88874-29-7
Molecular Formula	C49H69N13O11
Molecular Weight	1016.2 g/mol
Synonyms	[Sar1, Me-Tyr4]-Angiotensin II; Saralasin Acetate; Sarcosin1, N-Methyltyrosine4 Angiotensin II; 1-Sar-8-Ala Angiotensin II (variant); Angiotensin II antagonist; Angiotensin II receptor ligand; ATII analog; (Sar1,MeTyr4)-Ang II
EINECS	Contact for details

Quality Control

Every batch of Angiotensin II, Sar(1)-Me-Tyr(4)- is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for research and development purposes. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as assay purity, peptide content, and impurity profiles. Our quality commitment supports compliance with relevant standards for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 2.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.