Description

Fmoc-6-Aminohexanoic Acid CAS NO 88574-06-5 is a high-purity, protected amino acid derivative featuring a 6-aminohexanoic acid (6-Ahx) spacer linked to a fluorenylmethyloxycarbonyl (Fmoc) protecting group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), where it is used to introduce a flexible, hydrophilic spacer arm between peptide sequences and other molecules. It is essential for researchers and manufacturers in pharmaceutical development, bioconjugation, and proteomics who require reliable, high-quality intermediates for creating complex biomolecules. The product's design facilitates the synthesis of peptide-drug conjugates, labeled peptides, and materials for surface functionalization.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid for the automated synthesis of peptides, specifically to incorporate a 6-aminohexanoic acid linker.
• Peptide-Drug Conjugates (PDCs): Serves as a key spacer molecule to link cytotoxic drugs to targeting peptides, improving solubility and pharmacokinetics.
• Bioconjugation and Labeling: Used to attach fluorophores, biotin, or other reporter molecules to peptides and proteins via the free carboxyl group after Fmoc deprotection.
• Surface Modification: Functionalizes surfaces (e.g., biosensor chips, nanoparticles) by providing a terminal amino group for further covalent attachment of biomolecules.
• Antibody-Drug Conjugate (ADC) Research: Employed in the design and synthesis of linker-payload systems for next-generation ADCs.
• Combinatorial Chemistry: A valuable building block in libraries for drug discovery, enabling the rapid assembly of diverse compounds with spacer elements.

Basic Information

Product Name	Fmoc-6-Aminohexanoic Acid
CAS No.	88574-06-5
Molecular Formula	C₂₁H₂₃NO₄
Molecular Weight	353.41 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-6-aminohexanoic Acid; Fmoc-6-Ahx-OH; Fmoc-Ahx-OH; Fmoc-ε-Ahx-OH; N-α-Fmoc-6-aminohexanoic Acid; (6-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}hexanoic acid); Fmoc-NH-(CH2)5-COOH; Fmoc-6-Amino Caproic Acid
EINECS	Contact for details

Quality Control

Our Fmoc-6-Aminohexanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for peptide synthesis and pharmaceutical research. Certificates of Analysis (COA) are provided, detailing key parameters such as purity (HPLC), chiral purity, and moisture content. We adhere to relevant industry guidelines to support our customers in GMP-compliant development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.