Description

Ethyl 1-Amino-7-Chloro-6-Fluoro-1,4-Dihydro-4-Oxoquinoline-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of modern fluoroquinolone antibiotics, enabling the development of potent antimicrobial agents. It is essential for research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in the development and production of next-generation antibacterial drugs.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: Primary use in the synthesis of active pharmaceutical ingredients (APIs) such as Levofloxacin, Gatifloxacin, and other broad-spectrum antibacterial agents.
• Pharmaceutical Research & Development: Serves as a crucial scaffold for medicinal chemists exploring new antibacterial compounds with improved efficacy and reduced resistance.
• Fine Chemical Synthesis: Used in multi-step organic synthesis to construct complex quinoline-based molecular structures.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the cGMP production of antibiotic drug substances.
• Academic Research: Utilized in university and institutional labs for studying structure-activity relationships (SAR) in antimicrobial agents.

Basic Information

Product Name	Ethyl 1-Amino-7-Chloro-6-Fluoro-1,4-Dihydro-4-Oxoquinoline-3-Carboxylate
CAS No.	88569-30-6
Molecular Formula	C₁₂H₁₀ClFN₂O₃
Molecular Weight	284.67 g/mol
Synonyms	7-Chloro-6-fluoro-1,4-dihydro-4-oxo-1-(ethyl carboxy)-3-quinolinecarboxylic acid ethyl ester; Ethyl 7-chloro-6-fluoro-1,4-dihydro-4-oxo-1-(ethoxycarbonyl)-3-quinolinecarboxylate; 1-Amino-7-chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester; Levofloxacin intermediate; OFLX intermediate; ABT-255 intermediate; 88569-30-6; 1-Ethoxycarbonyl-7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 1-Amino-7-Chloro-6-Fluoro-1,4-Dihydro-4-Oxoquinoline-3-Carboxylate is manufactured under strict quality management systems. We provide material suitable for pharmaceutical synthesis, with specifications tailored to meet the requirements of cGMP production and ICH guidelines. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.