Description

Ac-4,5-Dehydro-Leu-Oh is a specialized, high-purity amino acid derivative used as a critical building block in advanced organic synthesis. This compound is valued for its unique unsaturated side chain, which introduces structural rigidity and specific reactivity into target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and bioactive compounds, where precise molecular architecture is essential for function.

Application

• Pharmaceutical Research & Development: A key intermediate in the synthesis of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used to incorporate a constrained, dehydro-leucine residue into peptide chains to study structure-activity relationships and enhance metabolic stability.
• Bioconjugation & Probe Synthesis: Serves as a building block for creating labeled peptides or affinity probes used in biochemical assays and diagnostic research.
• Academic & Industrial Research: Employed in medicinal chemistry programs to explore new chemical space and develop libraries of compounds for screening.
• Process Chemistry: Used in the scale-up and optimization of synthetic routes for complex molecules requiring this specific chiral synthon.

Basic Information

Product Name	Ac-4,5-Dehydro-Leu-Oh
CAS No.	88547-24-4
Molecular Formula	C8H13NO3
Molecular Weight	171.19 g/mol
Synonyms	N-Acetyl-4,5-dehydroleucine; N-Acetyl-dehydroleucine; Ac-DhLeu-OH; (S)-2-Acetamido-4-methylpent-4-enoic acid; 4,5-Dehydro-N-acetyl-L-leucine; N-Acetyl-δ4,5-leucine; N-Acetyl-4-methyl-4-pentenoic acid-2-amide
EINECS	Contact for details

Quality Control

Our Ac-4,5-Dehydro-Leu-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications. We support cGMP standards for materials intended for pharmaceutical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.