Description

Enkephalin-Leu, 4-Hydroxycinnamoyl(1)- CAS NO 88492-42-6 is a chemically modified peptide derivative of the endogenous opioid peptide [Leu]-enkephalin, incorporating a 4-hydroxycinnamoyl moiety. This modification is crucial for enhancing the peptide's stability and bioavailability, making it a valuable tool for advanced biochemical and pharmacological research. It is primarily utilized by research scientists and pharmaceutical developers in neuroscience, pain management research, and drug discovery programs.

Application

• Neuroscience Research: As a stable analog for studying opioid receptor (delta and mu) interactions, signaling pathways, and neuropeptide metabolism.
• Pharmacological Studies: Used in the development and screening of novel analgesic compounds and in structure-activity relationship (SAR) studies.
• Biochemical Assays: Serves as a reference standard or substrate in enzymatic stability assays and proteolysis studies.
• Drug Discovery: A key intermediate or molecular probe in the design of peptide-based therapeutics with improved pharmacokinetic profiles.
• Academic Research: Fundamental research on endogenous opioid systems, peptide chemistry, and medicinal chemistry.

Basic Information

Item	Details
Product Name	Enkephalin-Leu, 4-Hydroxycinnamoyl(1)-
CAS No.	88492-42-6
Molecular Formula	C34H41N5O8
Molecular Weight	647.72 g/mol
Synonyms	4-Hydroxycinnamoyl-[Leu5]-enkephalin; HOCinn-Leu-Enkephalin; Tyr-Gly-Gly-Phe-Leu(4-Hydroxycinnamoyl); [Leu5]-Enkephalin, 4-hydroxycinnamoyl derivative; 4-Hydroxycinnamoylleucine enkephalin; Opioid peptide analog; Cinnamoyl-modified enkephalin
EINECS	Contact for details

Quality Control

Our Enkephalin-Leu, 4-Hydroxycinnamoyl(1)- is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our analytical methods comply with standard pharmacopeial practices.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep containers sealed under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.