Description

Benzyloxycarbonyl-Phenylalanyl-Dehydrophenylalanine is a specialized protected dipeptide derivative featuring a dehydroamino acid residue. This compound is of significant value in advanced peptide synthesis and medicinal chemistry research, serving as a key building block for constructing complex peptide structures with specific conformational constraints. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and studying peptide structure-activity relationships.

Application

• Pharmaceutical Intermediate: A critical building block in the solid-phase and solution-phase synthesis of complex peptide-based drug candidates and bioactive peptides.
• Medicinal Chemistry Research: Used to introduce conformational constraints into peptide backbones, aiding in the study of structure-activity relationships (SAR) and the development of metabolically stable analogs.
• Protease Inhibitor Development: Serves as a core scaffold or intermediate in the design and synthesis of inhibitors targeting specific proteolytic enzymes.
• Bioconjugation & Labeling: The reactive dehydroalanine moiety can be utilized for selective bioconjugation strategies, such as Michael additions, to attach labels, tags, or other functional groups.
• Academic & Institutional Research: Employed in biochemical and biophysical studies to investigate peptide folding, stability, and protein-peptide interactions.
• Fine Chemical Synthesis: Acts as a chiral synthon for the asymmetric synthesis of non-natural amino acids and other complex organic molecules.

Basic Information

Product Name	Benzyloxycarbonyl-Phenylalanyl-Dehydrophenylalanine
CAS No.	88463-10-9
Molecular Formula	C26H22N2O5
Molecular Weight	442.47 g/mol
Synonyms	Z-Phe-δPhe-OH; Cbz-Phe-δPhe-OH; N-Carbobenzoxy-L-phenylalanyl-dehydrophenylalanine; Benzyloxycarbonyl-L-phenylalanyl-(Z)-dehydrophenylalanine; (Z)-2-((((Benzyloxy)carbonyl)-L-phenylalanyl)amino)-3-phenylacrylic acid; Z-L-Phe-δ-Z-L-Phe-OH; Nα-Cbz-L-Phenylalanyl-dehydro-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Benzyloxycarbonyl-Phenylalanyl-Dehydrophenylalanine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and spectroscopic identification (NMR, IR, MS), to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic and spectral data are provided to guarantee traceability, consistency, and reliability for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.