Description

H-Gly-Cys-Gly-Oh CAS NO 88440-55-5 is a synthetic tripeptide composed of glycine and cysteine residues, serving as a crucial building block and model compound in biochemical research. Its unique structure, featuring a central cysteine with a free thiol group, makes it highly valuable for studying redox biology, enzyme mechanisms, and peptide conjugation chemistry. This peptide is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors, particularly for applications in drug discovery, proteomics, and the development of diagnostic assays.

Application

• Pharmaceutical Research: Used as a key intermediate or reference standard in the development of novel therapeutic peptides and enzyme inhibitors.
• Bioconjugation & Protein Engineering: Serves as a linker or spacer molecule for attaching fluorophores, drugs, or other functional groups to proteins and antibodies via its reactive cysteine thiol.
• Antioxidant Studies: Acts as a model substrate to investigate the antioxidant properties and redox cycling behavior of glutathione-related systems.
• Biochemical Assay Development: Employed in calibrating assays for thiol quantification, protease activity, and oxidative stress markers.
• Academic & Industrial R&D: A fundamental tool for studying peptide structure, stability, and folding dynamics in various solvent environments.

Basic Information

Item	Detail
Product Name	H-Gly-Cys-Gly-Oh
CAS No.	88440-55-5
Molecular Formula	C7H13N3O4S
Molecular Weight	235.26 g/mol
Synonyms	Glycyl-L-cysteinylglycine; G-C-G; GCG tripeptide; L-Cysteinylglycylglycine; H-Gly-Cys-Gly-OH; NSC 334908; Glycine-Cysteine-Glycine; (2R)-2-Amino-3-[[2-[(2-aminoacetyl)amino]acetyl]sulfanyl]propanoic acid
EINECS	Contact for details

Quality Control

Our H-Gly-Cys-Gly-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and chiral analysis to ensure the correct stereochemistry. We provide full traceability and detailed Certificates of Analysis (COA) for every shipment, supporting research that demands high-purity, well-characterized reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) for long-term stability, as the compound is hygroscopic and easily oxidized. For short-term use, allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep the container in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay (Titration)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.