Description

(D-Pen2,Pen5)-Enkephalin CAS NO 88373-72-2 is a synthetic, cyclic pentapeptide analog of the endogenous opioid peptide [Met]-enkephalin, specifically engineered with D-penicillamine substitutions at positions 2 and 5. This modification confers significant metabolic stability and enhanced receptor selectivity, making it a critical research tool for studying the delta opioid receptor (DOR) system. It is primarily utilized by pharmaceutical researchers, neuroscientists, and biochemical suppliers engaged in advanced neuropharmacology and analgesic drug discovery programs.

Application

• Neuroscience Research: A highly selective delta opioid receptor (DOR) agonist used to investigate pain pathways, neuroprotection, and emotional behaviors in preclinical models.
• Pharmacology Studies: Serves as a reference standard for in vitro and in vivo assays to evaluate the potency, efficacy, and binding affinity of novel opioid compounds.
• Analgesic Drug Development: Used as a lead compound or template for designing new synthetic peptides with improved stability and reduced side-effect profiles for pain management.
• Biochemical Reagent: Supplied to laboratories and CROs (Contract Research Organizations) as a high-purity reagent for cell signaling studies and receptor characterization.
• Academic Research: Essential for university labs studying the molecular mechanisms of opioid receptors, tolerance, and dependence.

Basic Information

Product Name	(D-Pen2,Pen5)-Enkephalin
CAS No.	88373-72-2
Molecular Formula	C27H35N5O7S2
Molecular Weight	613.73 g/mol
Synonyms	DPDPE; [D-Pen2, D-Pen5]-Enkephalin; (D-Pen2,5)-Enkephalin; H-Tyr-D-Pen-Gly-Phe-D-Pen-OH; δ-Selective Enkephalin Analog; CID 443297; BDBM50397185; SCHEMBL23794
EINECS	Contact for details

Quality Control

Our (D-Pen2,Pen5)-Enkephalin is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot is subjected to comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and solvent residues is provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, dimethyl sulfoxide (DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.