Description

Neurotensin, Iodo-Tyr(11)- CAS NO 88096-16-6 is a chemically modified, radiolabeled analog of the endogenous neuropeptide neurotensin. This compound is a critical research tool for investigating neurotensin receptor (NTSR) pharmacology, distribution, and signaling pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and diagnostic developers focused on neuroscience, oncology, and metabolic disorders.

Application

• Receptor Binding Assays: Used as a high-affinity radioligand for in vitro binding studies to characterize and quantify neurotensin receptors (NTS1 and NTS2).
• Autoradiography: Essential for mapping the anatomical distribution of neurotensin receptors in brain slices and other tissues.
• Drug Discovery & Development: Serves as a key tool for screening and evaluating novel neurotensin receptor agonists or antagonists in preclinical research.
• Metabolic Studies: Employed in research exploring the role of neurotensin in regulating glucose metabolism, insulin secretion, and appetite.
• Oncology Research: Investigated for targeting neurotensin receptors overexpressed in certain cancers, such as pancreatic, prostate, and colon cancers.
• Internalization & Signaling Studies: Used to study receptor internalization kinetics and downstream signal transduction mechanisms.

Basic Information

Product Name	Neurotensin, Iodo-Tyr(11)- CAS NO 88096-16-6
CAS No.	88096-16-6
Molecular Formula	C₈₉H₁₂₇N₂₄O₂₃S₂
Molecular Weight	~1993.2 g/mol
Synonyms	Iodotyrosyl(11)-Neurotensin; [125I]-Tyr(11)-Neurotensin; [125I]-Neurotensin; Neurotensin (8-13), Iodo-Tyr(11)-; Neurotensin, [125I]Tyr11-; Neurotensin, monoiodo-Tyr(11)-; pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr(3-I)-Ile-Leu-OH; NT(8-13) Iodo-Tyr(11) analog
EINECS	Contact for details

Quality Control

Our Neurotensin, Iodo-Tyr(11)- CAS NO 88096-16-6 is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and radiochemical purity assessment. Certificates of Analysis (COA) detailing specific purity, specific activity, and analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage of solutions, aliquot and avoid repeated freeze-thaw cycles. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Radiochemical Purity	≥ 97%
Specific Activity	~2200 Ci/mmol (81.4 TBq/mmol)
Peptide Content	≥ 90% (by amino acid analysis)
Solubility	Soluble in water, dilute acetic acid, or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.