Description

Neurotensin, Iodo-Tyr(3)- is a chemically modified, radiolabeled analog of the endogenous neuropeptide neurotensin. This compound is specifically engineered for research applications requiring high-affinity binding and detection, primarily through its incorporation of an iodine moiety. It is an essential tool for scientists in the fields of neuroscience, endocrinology, and oncology, particularly for receptor binding studies, autoradiography, and the development of diagnostic imaging agents. The product is supplied with the CAS registry number 88096-15-5.

Application

• Neuroreceptor Research: Used as a high-affinity radioligand in binding assays to study the distribution, density, and pharmacology of neurotensin receptors (NTS1 and NTS2) in the central nervous system.
• Autoradiography: A critical reagent for mapping neurotensin receptor expression in brain slices and other tissue specimens with high spatial resolution.
• Drug Discovery & Development: Serves as a standard and tracer in high-throughput screening (HTS) campaigns to identify and characterize novel agonists or antagonists targeting neurotensin pathways.
• Oncology Research: Utilized in studies investigating the role of neurotensin receptors in cancer cell proliferation, with potential applications in developing targeted imaging and therapeutic agents.
• Biochemical Assay Development: Employed in the development and validation of competitive ELISA or other immunoassay formats for neurotensin detection.
• Metabolic Pathway Analysis: Aids in research on neurotensin's role in metabolic regulation, feeding behavior, and gastrointestinal function.

Basic Information

Product Name	Neurotensin, Iodo-Tyr(3)-
CAS No.	88096-15-5
Molecular Formula	C₈₉H₁₂₂N₂₄O₂₃S₂ * (Iodine)
Molecular Weight	~2090 g/mol (monoisotopic)
Synonyms	Iodo-Tyr³-Neurotensin; [I-Tyr³]-Neurotensin; Neurotensin (iodo-Tyr³); Neurotensin, 3-Iodo-Tyr-; pGlu-Leu-Tyr(3-I)-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu; NT(8-13) Iodo-Tyr³ analog; Neurotensin iodinated derivative; Neurotensin radioligand precursor.
EINECS	Contact for details

Quality Control

Every batch of Neurotensin, Iodo-Tyr(3)- is manufactured and analyzed under strict quality protocols to ensure identity, purity, and consistency for critical research. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and provide detailed results for key parameters including purity (HPLC), peptide content, and isotopic enrichment where applicable.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use quantities to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95%
Peptide Content (Amino Acid Analysis)	≥ 80%
Single Impurity (HPLC)	≤ 2.0%
Water Content (Karl Fischer)	≤ 5.0%
Solubility	Soluble in water, dimethyl sulfoxide (DMSO), acetic acid solution

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.