Description

4-Amino-1-[[2-Hydroxy-1-(Hydroxymethyl)Ethoxy]Methyl]-2(1H)-Pyrimidinone is a high-purity nucleoside analog building block of significant importance in advanced pharmaceutical synthesis. This compound matters as a critical intermediate for the development of novel antiviral and anticancer therapeutics, particularly in the synthesis of modified nucleosides. Pharmaceutical R&D teams and fine chemical manufacturers need this material for its precise molecular structure, which enables the creation of targeted active pharmaceutical ingredients (APIs) with enhanced efficacy.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Drug Research: Used in the R&D of prodrugs and nucleotide analogs targeting viral polymerases.
• Oncology Therapeutics: Serves as a precursor in the development of chemotherapeutic agents that interfere with DNA/RNA synthesis.
• Biochemical Research: Employed in studies of enzyme kinetics and nucleic acid metabolism as a substrate or inhibitor.
• Prodrug Synthesis: Utilized to create masked phosphate or lipid conjugates to improve drug bioavailability and targeting.
• Fine Chemical Synthesis: Acts as a specialized starting material for custom synthesis and contract manufacturing organizations (CMOs).

Basic Information

Item	Details
Product Name	4-Amino-1-[[2-Hydroxy-1-(Hydroxymethyl)Ethoxy]Methyl]-2(1H)-Pyrimidinone
CAS No.	87892-46-4
Molecular Formula	C8H13N3O4
Molecular Weight	215.21 g/mol
Synonyms	1-[(2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl]cytosine; 1-[(1,3-Dihydroxy-2-propoxy)methyl]cytosine; 1-[(2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl]-4-aminopyrimidin-2(1H)-one; Cytosine, 1-[(1,3-dihydroxy-2-propoxy)methyl]-; 1-(2,3-Dihydroxypropoxymethyl)cytosine; N4-Amino-1-(2,3-dihydroxypropoxymethyl)cytosine; Glycerol Derivative of Cytosine
EINECS	Contact for details

Quality Control

Our 4-Amino-1-[[2-Hydroxy-1-(Hydroxymethyl)Ethoxy]Methyl]-2(1H)-Pyrimidinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR, to ensure it meets the high standards required for pharmaceutical R&D and GMP synthesis. Certificates of Analysis (COA) with complete traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.