Description

4-(Difluoromethoxy)Phenol is a versatile fluorinated phenolic compound that serves as a critical building block in advanced chemical synthesis. Its unique difluoromethoxy group attached to the phenol ring makes it a valuable intermediate for introducing specific physicochemical properties into target molecules. This compound is primarily utilized by research and development teams, as well as production chemists, in the pharmaceutical and agrochemical industries. Its role is essential for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides and fungicides, where the difluoromethoxy moiety can improve lipophilicity and biological activity.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic display applications.
• Polymer Modification: Acts as a monomer or additive to introduce fluorine into polymer backbones, enhancing chemical resistance and thermal stability.
• Organic Synthesis Building Block: Employed in cross-coupling reactions and nucleophilic aromatic substitutions to construct complex molecular architectures.
• Material Science Research: Investigated for creating novel coatings and surface modifiers with specific dielectric or non-stick properties.

Basic Information

Product Name	4-(Difluoromethoxy)Phenol
CAS No.	87789-47-7
Molecular Formula	C7H6F2O2
Molecular Weight	160.12 g/mol
Synonyms	4-Hydroxyphenyl difluoromethyl ether; p-(Difluoromethoxy)phenol; 1-Hydroxy-4-(difluoromethoxy)benzene; Phenol, 4-(difluoromethoxy)-; Difluoromethoxy-p-phenol; 4-DFMP; DFMP
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)Phenol is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed batch-specific results are available upon request. We adhere to cGMP principles where applicable to guarantee consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.