Description

Boc-[15N]Tyr-Oh is a stable isotope-labeled derivative of the amino acid tyrosine, specifically enriched with nitrogen-15 at the amino group. This compound is essential for advanced research and development in fields requiring precise molecular tracking and quantification. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and academic research sectors for applications such as metabolic studies, proteomics, and as a critical building block for labeled peptides.

Application

• Isotope-Labeled Peptide Synthesis: Serves as a key protected, labeled amino acid precursor for the solid-phase or solution-phase synthesis of peptides containing 15N isotopes for NMR and mass spectrometry studies.
• Metabolic Pathway Analysis: Used as a tracer in metabolic flux analysis to study tyrosine metabolism and related biochemical pathways in biological systems.
• Proteomics & Quantitative Mass Spectrometry: Acts as an internal standard for the accurate quantification of proteins and peptides using techniques like SILAC (Stable Isotope Labeling by Amino acids in Cell culture).
• Pharmaceutical R&D: Employed in the research and development of new drug candidates, particularly for pharmacokinetic and pharmacodynamic studies involving isotope labeling.
• NMR Spectroscopy Standards: Provides a well-defined, isotopically enriched standard for nuclear magnetic resonance spectroscopy, aiding in structural elucidation and dynamics studies.
• Biochemical Research Reagent: Utilized in various enzymatic assays and studies of protein-protein interactions where a labeled tyrosine residue is required.

Basic Information

Product Name	Boc-[15N]Tyr-Oh
CAS No.	87713-11-9
Molecular Formula	C14H1815NNO5
Molecular Weight	284.30 g/mol (for 15N labeled form)
Synonyms	N-α-(tert-Butoxycarbonyl)-L-tyrosine-15N; Boc-L-tyrosine-15N; (2S)-3-(4-Hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonyl-15N]aminopropanoic acid; tert-Butoxycarbonyl-15N-L-tyrosine; BOC-TYR(15N)-OH; N-Boc-L-tyrosine-15N; L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl-15N]-
EINECS	Contact for details

Quality Control

Every batch of Boc-[15N]Tyr-Oh is subjected to rigorous analytical testing to ensure high isotopic and chemical purity, meeting the stringent requirements of research and pharmaceutical applications. Our quality assurance protocols include comprehensive characterization by NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment (15N)	≥98 atom % 15N
Optical Rotation	[α]D20: Contact for details
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.