Description

2(1H)-Pyrimidinone, 5-Ethynyl-4-Methyl- (9Ci) is a specialized heterocyclic building block featuring a pyrimidinone core substituted with an ethynyl and a methyl group. This compound is valued for its unique molecular architecture, which makes it a versatile intermediate in advanced organic synthesis and pharmaceutical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecules and exploring new chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for targeted therapies.
• Agrochemical Research: Used in the synthesis of new pesticide and herbicide candidates, leveraging its heterocyclic structure for biological activity.
• Fine Chemical Synthesis: Acts as a building block for creating complex molecules used in material science, dyes, and specialty chemicals.
• Academic & Industrial R&D: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and library synthesis.
• Chemical Biology Probes: The ethynyl group allows for potential use in click chemistry applications for labeling and bioconjugation.

Basic Information

Product Name	2(1H)-Pyrimidinone, 5-Ethynyl-4-Methyl- (9Ci)
CAS No.	87573-91-9
Molecular Formula	C7H6N2O
Molecular Weight	134.14 g/mol
Synonyms	5-Ethynyl-4-methylpyrimidin-2(1H)-one; 4-Methyl-5-ethynyl-1,2-dihydropyrimidin-2-one; 5-Ethynyl-4-methyl-1H-pyrimidin-2-one; 4-Methyl-5-ethynyl-2(1H)-pyrimidinone; 5-Ethynyl-4-methyl-2-pyrimidinol; 87573-91-9
EINECS	Contact for details

Quality Control

Our 2(1H)-Pyrimidinone, 5-Ethynyl-4-Methyl- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (by HPLC), related substances, and residual solvents are provided with every shipment. We adhere to cGMP principles for the manufacture of advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.