Description

[(1R,2S,5S)-8-Methyl-8-Azabicyclo[3.2.1]Oct-2-Yl] 2,2-Diphenyl-2-Phenylmethoxy-Acetate Hydrochloride is a high-purity, complex organic salt with a defined stereochemistry, making it a critical intermediate for advanced pharmaceutical synthesis. Its value lies in its role as a key chiral building block for the development of active pharmaceutical ingredients (APIs), particularly in the central nervous system and analgesic therapeutic areas. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the synthesis of novel drug candidates and generic pharmaceuticals.

Application

• Pharmaceutical Intermediate: A crucial chiral precursor in the multi-step synthesis of complex drug molecules, particularly tropane alkaloid derivatives.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the research and development of new chemical entities (NCEs) targeting neurological pathways.
• Medicinal Chemistry Research: Serves as a standard or building block for structure-activity relationship (SAR) studies in drug discovery programs.
• Process Development & Scale-Up: Employed in optimizing synthetic routes from laboratory to pilot and commercial manufacturing scales.
• Analytical Reference Standard: Used as a high-purity standard for method development, validation, and quality control testing in pharmaceutical analysis.

Basic Information

Product Name	[(1R,2S,5S)-8-Methyl-8-Azabicyclo[3.2.1]Oct-2-Yl] 2,2-Diphenyl-2-Phenylmethoxy-Acetate Hydrochloride
CAS No.	87421-58-7
Molecular Formula	C29H31NO4·HCl
Molecular Weight	494.02 g/mol
Synonyms	8-Methyl-8-azabicyclo[3.2.1]octan-2-yl 2,2-diphenyl-2-(phenylmethoxy)acetate hydrochloride; Tropine 2,2-diphenyl-2-(benzyloxy)acetate hydrochloride; Benzilic acid tropine ester hydrochloride; 3-Tropanyl benzilate hydrochloride; Benziloyloxytropane hydrochloride
EINECS	Contact for details

Quality Control

Every batch of [(1R,2S,5S)-8-Methyl-8-Azabicyclo[3.2.1]Oct-2-Yl] 2,2-Diphenyl-2-Phenylmethoxy-Acetate Hydrochloride is manufactured under strict quality management systems. We provide comprehensive analytical documentation to support regulatory filings (e.g., DMFs, CEPs). Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, chiral purity, and impurity profiles as per client specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.