Description

(2R,3R)-2-Amino-3-Hydroxy-4-Methyl-Valeric Acid CAS NO 87421-24-7 is a high-purity, non-proteinogenic amino acid derivative characterized by its specific (2R,3R) stereochemistry. This compound serves as a critical chiral building block and intermediate in the synthesis of complex pharmaceuticals and bioactive molecules, where stereochemical integrity is paramount for efficacy and safety. It is essential for research and production in the pharmaceutical, biotechnology, and fine chemical sectors, particularly for developing peptide-based therapeutics, enzyme inhibitors, and novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel antibiotics, antiviral agents, and other therapeutic compounds.
• Peptide Synthesis: Used as a protected or unprotected amino acid derivative in solid-phase and solution-phase peptide chemistry to introduce specific structural motifs.
• Biochemical Research: Serves as a standard, inhibitor, or substrate in enzymatic studies and metabolic pathway research.
• Prodrug Development: Incorporated into prodrug architectures to modify solubility, bioavailability, and targeted delivery.
• Asymmetric Catalysis: Employed as a chiral ligand or auxiliary in asymmetric synthesis to induce stereoselectivity.
• Fine Chemical Production: A valuable intermediate for manufacturing specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.

Basic Information

Product Name	(2R,3R)-2-Amino-3-Hydroxy-4-Methyl-Valeric Acid
CAS No.	87421-24-7
Molecular Formula	C6H13NO3
Molecular Weight	147.17 g/mol
Synonyms	(2R,3R)-2-Amino-3-hydroxy-4-methylpentanoic acid; (2R,3R)-3-Hydroxy-4-methyl-2-aminopentanoic acid; D-three-3-Hydroxy-4-methyl-2-aminopentanoic acid; (2R,3R)-3-Hydroxy-4-methylnorvaline; (2R,3R)-Hmn; (2R,3R)-2-Amino-3-hydroxy-4-methylvaleric acid; (2R,3R)-AHMVA; A non-proteinogenic amino acid derivative.
EINECS	Contact for details

Quality Control

Our (2R,3R)-2-Amino-3-Hydroxy-4-Methyl-Valeric Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for assay and enantiomeric purity, IR and NMR for structural confirmation, and rigorous tests for residual solvents and impurities. We provide Certificates of Analysis (COA) with each shipment to ensure full traceability and compliance with your research or cGMP-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.