Description

Somatotropin Releasing Hormone (1-40)-OH, Ala(34)-Ser(38)-Arg(40)- is a synthetic peptide analog of growth hormone-releasing hormone (GHRH). This compound is engineered for enhanced stability and biological activity, making it a critical research tool for studying growth hormone regulation and secretion pathways. It is primarily utilized by pharmaceutical researchers, biotech R&D departments, and academic institutions focused on endocrinology, metabolic disorders, and peptide therapeutics development.

Application

• Biomedical Research: Fundamental studies on the somatotropic axis, growth hormone (GH) pulsatility, and feedback mechanisms.
• Drug Discovery & Preclinical Studies: Serving as a reference standard or active pharmaceutical ingredient (API) in the development of novel GHRH-based therapeutics for growth disorders.
• Endocrinology Assays: Used in in vitro and in vivo models to assess pituitary function and the potency of GHRH receptor agonists/antagonists.
• Metabolic Research: Investigation of the role of GHRH in metabolism, body composition, and age-related hormonal decline.
• Peptide Chemistry & Stability Studies: As a model compound for analyzing the structure-activity relationships (SAR) and metabolic stability of modified peptide hormones.
• Reference Standard: For quality control and analytical method development (e.g., HPLC, MS) in peptide manufacturing and regulatory submissions.

Basic Information

Product Name	Somatotropin Releasing Hormone (1-40)-OH, Ala(34)-Ser(38)-Arg(40)-
CAS No.	87396-41-6
Molecular Formula	C194H317N61O58S
Molecular Weight	4545.1 g/mol
Synonyms	GHRH (1-40)-OH, Ala34, Ser38, Arg40; Growth Hormone-Releasing Hormone (1-40), human, Ala34, Ser38, Arg40; hGHRH(1-40)-OH, [Ala34, Ser38, Arg40]; Somatocrinin analog; GRF (1-40), human, [Ala34, Ser38, Arg40]; Growth hormone-releasing factor (1-40) amide, human, [Ala34, Ser38, Arg40]-; [Ala34, Ser38, Arg40]-hGHRH(1-40)-OH
EINECS	Contact for details

Quality Control

Our Somatotropin Releasing Hormone (1-40)-OH, Ala(34)-Ser(38)-Arg(40)- is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing purity, peptide content, and related substances. Production can be aligned with cGMP guidelines for advanced research and pre-clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.