Description

4,5-Dehydro-Leucine is a non-proteinogenic amino acid derivative characterized by a dehydro modification on its side chain. This unique structure makes it a valuable chiral building block and intermediate in advanced organic synthesis and pharmaceutical research. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications such as peptide modification and the development of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used for the synthesis and modification of peptides to study structure-activity relationships and enhance metabolic stability.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies and metabolic pathway investigations.
• Fine Chemical Synthesis: Acts as a specialized building block for the preparation of complex organic molecules and natural product analogs.
• Proteomics & Cell Biology: Can be incorporated into peptides or proteins as a probe to study protein function, folding, and interactions.

Basic Information

Product Name	4,5-Dehydro-Leucine
CAS No.	87392-13-0
Molecular Formula	C6H11NO2
Molecular Weight	129.16 g/mol
Synonyms	(2S)-2-Amino-4-methylpent-4-enoic acid; (S)-2-Amino-4-methyl-4-pentenoic acid; 4-Methyl-4-pentenoic acid, 2-amino-, (S)-; L-4,5-Dehydroleucine; 4,5-Didehydro-L-leucine; (S)-4,5-Dehydroleucine; 2-Amino-4-methyl-4-pentenoic acid
EINECS	Contact for details

Quality Control

Our 4,5-Dehydro-Leucine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and synthesis. A Certificate of Analysis (COA) detailing specific results for identity, purity, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.