Description

Angiotensin II, Sar(1)-4-Azido-Phe(8)- is a synthetic, photoactivatable analog of the potent vasoconstrictor peptide Angiotensin II, specifically engineered for research applications. This compound is a critical tool for investigating the Angiotensin II type 1 (AT1) receptor's structure, function, and signaling pathways through covalent cross-linking studies. It is primarily utilized by researchers and pharmaceutical developers in the fields of cardiovascular pharmacology, biochemistry, and medicinal chemistry for advanced receptor mapping and drug discovery initiatives.

Application

• Receptor Binding and Mapping Studies: Used as a photoaffinity labeling agent to covalently bind and identify the active sites of Angiotensin II receptors (AT1).
• Biochemical Research: A key reagent for probing the structure-activity relationships (SAR) of the angiotensin system and understanding ligand-receptor interactions.
• Drug Discovery & Development: Facilitates the design and screening of novel antagonists or modulators for the renin-angiotensin system (RAS) pathway.
• Signal Transduction Analysis: Employed to study downstream signaling cascades initiated by AT1 receptor activation in various cell types.
• Academic and Pharmaceutical R&D: Essential for basic and applied research in hypertension, heart failure, and renal disease mechanisms.

Basic Information

Product Name	Angiotensin II, Sar(1)-4-Azido-Phe(8)-
CAS No.	87262-02-0
Molecular Formula	C49H68N14O11
Molecular Weight	1021.2 g/mol
Synonyms	[Sar1,4-N3-Phe8]-Angiotensin II; 4-Azido-Phenylalanine8-Angiotensin II; Saralasin azide derivative; Photoaffinity Angiotensin II analog; AT1 receptor photoaffinity ligand; Angiotensin II azido analog; Sar(1)-4-Azido-Phe(8)-Ang II
EINECS	Contact for details

Quality Control

Every batch of Angiotensin II, Sar(1)-4-Azido-Phe(8)- is produced and analyzed under strict quality protocols to ensure high purity and batch-to-batch consistency for research reproducibility. Our quality assurance includes comprehensive analytical testing via HPLC, MS, and NMR. A detailed Certificate of Analysis (COA) containing purity, identity confirmation, and handling data is provided with each shipment to support your compliance and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in DMSO, Acetic Acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.