Description

2-(3-Amino-3-Oxo-1-Propenyl)-5,10,11,11A-Tetrahydro-9-Hydroxy-8-Methyl-5-Oxo-1H-Pyrrolo[2,1-C][1,4]Benzodiazepine-11-Sulfinic Acid Sodium Salt is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of novel therapeutic agents, particularly in the development of targeted oncology treatments and specialized antibiotics. It is primarily required by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the production of next-generation benzodiazepine-derived active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel antitumor and antimicrobial agents.
• Oncology Drug Research: Used in the research and development of targeted cancer therapies, leveraging its benzodiazepine core for DNA interaction.
• Antibiotic Development: A crucial precursor in the synthesis of advanced antibiotic compounds, particularly those in the pyrrolobenzodiazepine (PBD) class.
• Bioconjugation: Utilized in the creation of antibody-drug conjugates (ADCs) due to its reactive functional groups suitable for linker attachment.
• Academic & Contract Research: Employed in university and CRO laboratories for mechanistic studies and the exploration of new chemical entities (NCEs).
• Process Chemistry: Used for scale-up and optimization studies in pilot plants and commercial API manufacturing.

Basic Information

Item	Detail
Product Name	2-(3-Amino-3-Oxo-1-Propenyl)-5,10,11,11A-Tetrahydro-9-Hydroxy-8-Methyl-5-Oxo-1H-Pyrrolo[2,1-C][1,4]Benzodiazepine-11-Sulfinic Acid Sodium Salt
CAS No.	87037-81-8
Molecular Formula	C17H16N3NaO6S
Molecular Weight	413.38 g/mol
Synonyms	SJG-136 Intermediate; PBD Sulfinate Sodium Salt; DC-81 Sulfinic Acid Sodium Salt; SJG-136 Sulfinate; 11-Deoxy-11-sulfinyl-SJG-136 Sodium Salt; Pyrrolo[2,1-c][1,4]benzodiazepine sulfinate; Antibiotic DC-81 derivative sodium salt
EINECS	Contact for details

Quality Control

Our 2-(3-Amino-3-Oxo-1-Propenyl)-5,10,11,11A-Tetrahydro-9-Hydroxy-8-Methyl-5-Oxo-1H-Pyrrolo[2,1-C][1,4]Benzodiazepine-11-Sulfinic Acid Sodium Salt is manufactured under strict GMP-like conditions to ensure the highest standards of purity and consistency required for pharmaceutical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.