Description

L-Proline, 4-Hydroxy-1-(2-Hydroxyethyl)-, trans- (9Ci) is a high-purity, non-proteinogenic amino acid derivative with a unique hydroxyethyl substitution on the proline ring. This specialized structure makes it a valuable chiral building block and intermediate for advanced organic synthesis and pharmaceutical research. It is essential for industries requiring precise molecular scaffolds to develop novel active pharmaceutical ingredients (APIs), peptide mimetics, and complex biochemical probes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for cardiovascular and neurological targets.
• Peptide Chemistry: Used to introduce conformational constraints and enhance the metabolic stability of synthetic peptides and peptidomimetics.
• Biochemical Research: Serves as a precursor or standard in enzymatic studies and metabolic pathway analysis.
• Asymmetric Synthesis: Employed as a ligand or catalyst component in stereoselective organic transformations.
• Cosmetic & Personal Care Actives: Investigated for use in advanced skincare formulations targeting collagen synthesis and skin repair.
• Agrochemical Development: Utilized in the synthesis of novel, biologically active compounds for crop protection.

Basic Information

Product Name	L-Proline, 4-Hydroxy-1-(2-Hydroxyethyl)-, trans- (9Ci)
CAS No.	87026-08-2
Molecular Formula	C7H13NO4
Molecular Weight	175.18 g/mol
Synonyms	trans-4-Hydroxy-1-(2-hydroxyethyl)-L-proline; (2S,4R)-4-Hydroxy-1-(2-hydroxyethyl)pyrrolidine-2-carboxylic acid; 1-(2-Hydroxyethyl)-4-hydroxy-L-proline; Hydroxyethylhydroxyproline; L-4-Hydroxy-1-(2-hydroxyethyl)proline; HYP(1-He); A building block for collagen analogs.
EINECS	Contact for details

Quality Control

Our L-Proline, 4-Hydroxy-1-(2-Hydroxyethyl)-, trans- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	Contact for details
Chiral Purity (HPLC)	≥ 99.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.