Description

Angiotensin-II, Sar-Arg-Val-Tyr-Val-His-Pro-(2',3',4',5',6'-Pentabromo)-Phe is a synthetic, brominated peptide analog of the potent vasoconstrictor hormone Angiotensin II. This modified compound is of significant interest for advanced biochemical and pharmacological research, particularly in the study of receptor-ligand interactions and signal transduction pathways. It serves as a critical tool for scientists in pharmaceutical R&D and academic institutions investigating cardiovascular systems, enzyme inhibition, and peptide hormone mechanisms.

Application

• Biochemical Research: Used as a specialized probe or antagonist in studies of the renin-angiotensin system (RAS) and angiotensin receptor (AT1/AT2) binding assays.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the discovery and development of novel cardiovascular therapeutics and enzyme inhibitors.
• Enzymology Studies: Employed to investigate the activity and inhibition of angiotensin-converting enzyme (ACE) and other related proteases.
• Peptide Chemistry: Acts as a model compound for studying the effects of halogenation (bromination) on peptide stability, bioactivity, and receptor selectivity.
• Diagnostic Reagent Manufacturing: Potential use in the formulation of high-sensitivity assay kits for clinical research and diagnostic applications.

Basic Information

Product Name	Angiotensin-II, Sar-Arg-Val-Tyr-Val-His-Pro-(2',3',4',5',6'-Pentabromo)-Phe
CAS No.	87023-81-2
Molecular Formula	C53H72Br5N15O12
Molecular Weight	~1467.7 g/mol
Synonyms	[Sar1, (2',3',4',5',6'-Pentabromo)Phe8]-Angiotensin II; Pentabromophenylalanine8-Angiotensin II Analog; Brominated Angiotensin II Peptide; Angiotensin II Pentabromo Derivative; ATII Brominated Analog; [Sar1, Br5Phe8]-Ang II; Angiotensin II Receptor Probe
EINECS	Contact for details

Quality Control

Our Angiotensin-II, Sar-Arg-Val-Tyr-Val-His-Pro-(2',3',4',5',6'-Pentabromo)-Phe is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and MS for identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 2.0%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Acetonitrile/Water mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.