Description

Trt-Glu(Otbu)-Oh Dcha is a protected glutamic acid derivative, specifically the tert-butyl ester of N-trityl-L-glutamic acid, supplied as a dicyclohexylamine (DCHA) salt. This compound is a critical building block in the synthesis of complex peptides and pharmaceutical intermediates, offering enhanced solubility and stability during coupling reactions. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and advanced biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid derivative for the controlled incorporation of glutamic acid into peptide chains.
• Pharmaceutical Intermediate: For the research and production of peptide-based drugs, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation: Serving as a linker or functional handle for attaching peptides to other molecules, such as polymers, dyes, or drug delivery systems.
• Chemical Biology Research: Used in the study of protein-protein interactions and the development of bioactive peptide probes.
• Fine Chemical Synthesis: As a chiral synthon in the asymmetric synthesis of more complex organic molecules.

Basic Information

Product Name	Trt-Glu(Otbu)-Oh Dcha
CAS No.	86967-51-3
Molecular Formula	C34H50N2O5
Molecular Weight	566.78 g/mol
Synonyms	Nα-Trityl-L-glutamic acid 1-tert-butyl ester dicyclohexylamine salt; (2S)-2-[(Tritylamino)carbonyl]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid compound with N-cyclohexylcyclohexanamine; Fmoc-Glu(OtBu)-OH DCHA salt (common abbreviation); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamic acid 5-tert-butyl ester dicyclohexylamine salt; Boc-Glu(OtBu)-OH DCHA (alternative protection); L-Glutamic acid, N-(triphenylmethyl)-, 1-(1,1-dimethylethyl) ester, compd. with dicyclohexylamine; Protected Glutamic Acid DCHA Salt.
EINECS	Contact for details

Quality Control

Our Trt-Glu(Otbu)-Oh Dcha is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.