Description

Neurokinin B is a potent decapeptide belonging to the tachykinin family of neuropeptides, which plays a critical role in various physiological signaling pathways. This compound is essential for advanced research in neuroendocrinology and the development of targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, reproductive biology, and pain management.

Application

• Neuroscience Research: Used as a standard and tool compound for studying tachykinin receptor (NK3) signaling, neuronal excitability, and synaptic transmission.
• Drug Discovery & Development: Serves as a key reference molecule in high-throughput screening (HTS) assays and pharmacological profiling for developing NK3 receptor antagonists and modulators.
• Endocrinology Studies: Critical for investigating its role in the hypothalamic-pituitary-gonadal axis, particularly in puberty onset and reproductive function.
• Biomarker & Diagnostic Research: Employed in the development of immunoassays (ELISA, RIA) to quantify Neurokinin B levels in biological samples for clinical research.
• Cell Signaling & Pathway Analysis: Applied in cell-based assays to elucidate intracellular signaling cascades activated by the NK3 receptor.
• Academic & Contract Research: A fundamental reagent for university laboratories and CROs (Contract Research Organizations) conducting basic and applied pharmacological research.

Basic Information

Product Name	Neurokinin B
CAS No.	86933-75-7
Molecular Formula	C₅₅H₈₀N₁₈O₁₃S₂
Molecular Weight	1217.5 g/mol
Synonyms	Neurokinin B (human, bovine, canine, porcine, rat); Tachykinin 3 (4-10); TAC3 (4-10); NKB; Neuromedin K; Neurokinin Beta; Substance K; [Asp⁵,MePhe⁸]-Substance P(5-11); H-Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH₂
EINECS	Contact for details

Quality Control

Our Neurokinin B is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to relevant standards for research-grade peptides, ensuring reliability for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Conforms to theoretical composition
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.