Description

(D-Pro4,D-Trp7,9,10)-Substance P (4-11) CAS NO 86917-57-9 is a synthetic peptide antagonist of the neurokinin-1 (NK1) receptor, derived from the native Substance P sequence. This compound is a critical research tool for studying neurogenic inflammation, pain transmission, and the role of tachykinins in various physiological and pathological processes. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on neuroscience, immunology, and drug discovery.

Application

• Neuroscience Research: As a selective NK1 receptor antagonist for investigating the role of Substance P in pain signaling, migraine, and central nervous system disorders.
• Pharmacological Studies: Used in in vitro and in vivo assays to characterize receptor binding, signal transduction, and to validate experimental models of inflammation and nociception.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of novel analgesic and anti-inflammatory therapeutics targeting the tachykinin pathway.
• Immunology Research: For studying neuro-immune interactions, as Substance P is involved in modulating immune cell function and neurogenic inflammation.
• Biochemical Reagent: Used in enzyme-linked immunosorbent assays (ELISAs), radioimmunoassays (RIAs), and other analytical techniques to quantify Substance P or block its activity.

Basic Information

Item	Details
Product Name	(D-Pro4,D-Trp7,9,10)-Substance P (4-11)
CAS No.	86917-57-9
Molecular Formula	C68H89N17O11
Molecular Weight	1304.5 g/mol
Synonyms	[D-Pro4, D-Trp7,9,10]-Substance P (4-11); Substance P (4-11), [D-Pro4, D-Trp7,9,10]-; [D-Pro4,D-Trp7,9,10]-SP(4-11); NK1 Receptor Antagonist (SP derivative); SP(4-11) antagonist; Tachykinin NK1 antagonist; (Arg-Pro-Lys-Pro-D-Pro-Gln-D-Trp-Phe-D-Trp-Leu-D-Trp-NH2); (Arg-Pro-Lys-Pro-D-Pro-Gln-D-Trp-Phe-D-Trp-Leu-D-Trp-amide)
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality systems. Each batch of (D-Pro4,D-Trp7,9,10)-Substance P (4-11) is characterized using advanced analytical techniques including HPLC and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at -20°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Conforms to theoretical composition
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.