Description

Substance P (4-11), Pro(4)-Val(8)-Trp(7,9,10)- is a specific, truncated peptide fragment of the neuropeptide Substance P. This compound is a critical research tool for investigating the structure-activity relationships and specific receptor interactions of Substance P, particularly focusing on its C-terminal region. It is primarily utilized by pharmaceutical researchers, neuroscientists, and biochemical suppliers in the fields of neuroscience research, drug discovery, and biochemical assay development.

Application

• Neuroscience Research: Used as a selective agonist/antagonist to study Substance P receptor subtypes (NK1, NK2, NK3) and their signaling pathways in the central and peripheral nervous systems.
• Pharmacological Studies: Essential for in vitro and in vivo assays to evaluate the biological activity, potency, and metabolic stability of Substance P analogs.
• Drug Discovery & Development: Serves as a key reference standard and intermediate in the design and synthesis of novel neurokinin receptor-targeting therapeutics for pain, inflammation, and CNS disorders.
• Biochemical Reagent: Employed in enzyme-linked immunosorbent assays (ELISAs), radioimmunoassays (RIAs), and other diagnostic or research kits to detect and quantify Substance P activity.
• Cell Signaling & Physiology: Applied in cell culture studies to investigate the role of Substance P in processes like neurogenic inflammation, nociception, and smooth muscle contraction.
• Academic & Institutional Research: A fundamental reagent for universities and research institutes conducting basic science on peptide hormones and neuropeptides.

Basic Information

Product Name	Substance P (4-11), Pro(4)-Val(8)-Trp(7,9,10)-
CAS No.	86917-56-8
Molecular Formula	C58H78N14O9
Molecular Weight	1107.3 g/mol
Synonyms	Substance P Fragment 4-11; [pGlu6,Pro9]-Substance P (6-11); [pGlu6,Pro9]-SP(6-11); Substance P (6-11) analog; Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (modified); Neurokinin receptor ligand; SP (4-11) analog; [Pro4, Val8, Trp7,9,10]-Substance P (4-11)
EINECS	Contact for details

Quality Control

Our Substance P (4-11) fragment is manufactured under controlled conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. All products undergo rigorous quality testing, including HPLC for purity verification and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided with each batch to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.