Description

n-Tertiary-Butyloxycarbonyl-Leucyl-Phenylalanine-Ethanolamide is a protected dipeptide derivative, specifically a leucine-phenylalanine conjugate with an ethanolamide C-terminus and a Boc-protected N-terminus. This compound is a crucial building block (synthon) in solid-phase and solution-phase peptide synthesis, offering precise control over peptide chain assembly. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for developing novel therapeutic peptides and biochemical probes.

Application

• Pharmaceutical Intermediates: As a key protected fragment in the synthesis of complex peptide-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a substrate or precursor in enzymatic studies and metabolic pathway investigations.
• Peptide Library Construction: A fundamental component for generating combinatorial peptide libraries for drug discovery and screening.
• Protease Inhibitor Development: Serves as a core structure for designing and synthesizing potential protease inhibitors.
• Custom Peptide Synthesis: Employed by CROs and CDMOs for the custom manufacturing of specific peptide sequences for clients.
• Academic Research: A valuable reagent in university and institutional labs for studying peptide structure, function, and synthesis methodologies.

Basic Information

Product Name	n-Tertiary-Butyloxycarbonyl-Leucyl-Phenylalanine-Ethanolamide
CAS No.	86810-21-1
Molecular Formula	C24H37N3O6
Molecular Weight	463.57 g/mol
Synonyms	Boc-Leu-Phe-NHCH2CH2OH; Boc-L-Leucyl-L-phenylalaninol; N-(tert-Butoxycarbonyl)-L-leucyl-L-phenylalaninol; tert-Butyl (2S)-4-methyl-1-[[(2S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopentan-2-ylcarbamate; L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-, (2S)-1-[[(2S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropyl]amino]-1-oxo-3-phenylpropyl] ester; Peptide Synthesis Building Block 86810-21-1
EINECS	Contact for details

Quality Control

Our n-Tertiary-Butyloxycarbonyl-Leucyl-Phenylalanine-Ethanolamide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for pharmaceutical research and development. Comprehensive Certificates of Analysis (COA) detailing identity, purity (HPLC), and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.