Description

Tyr-Somatostatin-28 CAS NO 86649-84-5 is a synthetic, biologically active peptide analog of the endogenous hormone somatostatin, modified with a tyrosine residue. This modification is critical for research applications requiring radiolabeling, typically with iodine-125, for receptor binding studies and metabolic pathway analysis. It is an essential tool for pharmaceutical R&D, academic research, and diagnostic development focused on neuroendocrinology, oncology, and metabolic disorders.

Application

• Biochemical Research: Used as a high-affinity ligand in receptor binding assays and autoradiography to study somatostatin receptor (SSTR) distribution and density.
• Pharmaceutical Development: Serves as a key reference standard and precursor in the development of novel radiolabeled diagnostic imaging agents and targeted therapeutics.
• Metabolic Studies: Employed in vitro and in vivo to investigate the inhibitory effects of somatostatin on hormone secretion (e.g., growth hormone, insulin, glucagon).
• Oncology Research: Utilized in the study of somatostatin receptor-positive tumors, aiding in the development of receptor-targeted cancer treatments.
• Antibody Production: Acts as an immunogen for generating specific antibodies used in immunoassays and immunohistochemistry.

Basic Information

Product Name	Tyr-Somatostatin-28
CAS No.	86649-84-5
Molecular Formula	C149H220N42O43S3
Molecular Weight	~3359.8 g/mol
Synonyms	Tyr-Somatostatin 28; Tyr-SST-28; Somatostatin-28 (Tyr); H-Tyr-Somatostatin-28-OH; Tyr-SRIF-28; Tyr-Somatotropin Release-Inhibiting Factor-28; [Tyr0]-Somatostatin-28; [Tyr1]-Somatostatin-28
EINECS	Contact for details

Quality Control

Our Tyr-Somatostatin-28 is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing all specifications and test results are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Assessed by receptor binding assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.