Description

Glucagon, 12-(N(6)-(4-Azidophenylamidino)Lys)- is a chemically modified derivative of the peptide hormone glucagon, featuring a photoactivatable aryl azide group at a specific lysine residue. This compound is a critical research-grade biochemical tool designed for advanced proteomic and molecular biology studies, enabling the covalent cross-linking and identification of glucagon receptor interactions. It is essential for scientists and R&D teams in the pharmaceutical and biotechnology sectors who are engaged in hormone receptor research, drug discovery, and the development of novel therapeutic agents for metabolic disorders.

Application

• Photoaffinity Labeling Studies: Used as a photoaffinity probe to covalently label and map the binding sites of glucagon receptors.
• Receptor Mapping & Characterization: Critical for identifying and characterizing glucagon receptor subtypes and their interaction domains.
• Drug Discovery Platforms: Serves as a key reagent in high-throughput screening assays for discovering and optimizing new glucagon receptor antagonists or agonists.
• Structural Biology Research: Aids in the structural elucidation of hormone-receptor complexes through cross-linking mass spectrometry (XL-MS).
• Metabolic Disease Research: Employed in studies focused on diabetes, obesity, and other metabolic syndromes to understand glucagon signaling pathways.
• Bioconjugation & Probe Development: Acts as a starting material for creating more complex diagnostic or therapeutic conjugates.

Basic Information

Product Name	Glucagon, 12-(N(6)-(4-Azidophenylamidino)Lys)-
CAS No.	86611-89-4
Molecular Formula	C159H238N48O49S
Molecular Weight	3488.9 g/mol
Synonyms	12-(N(6)-(4-Azidophenylamidino)Lys)-Glucagon; Glucagon derivative, 12-(N(6)-(4-azidophenylamidino)lysine); 4-Azidophenylamidino-Glucagon; Photoactivatable Glucagon; Glucagon aryl azide; Glucagon photoaffinity label; Glucagon cross-linking reagent
EINECS	Contact for details

Quality Control

Our Glucagon, 12-(N(6)-(4-Azidophenylamidino)Lys)- is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research. Each lot undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and functional activity assays. A detailed Certificate of Analysis (COA) is provided, documenting all specifications and test results to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.