Description

Pyrimidine, 4-Ethynyl-2,6-Dimethyl- (9Ci) is a specialized pyrimidine derivative featuring an ethynyl substituent, which serves as a versatile synthetic handle for further chemical elaboration. This compound is of significant value as a key pharmaceutical intermediate and a building block in advanced organic synthesis, particularly for creating complex heterocyclic systems. It is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries who require high-purity, functionalized heterocycles for drug discovery and specialty chemical manufacturing.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for antiviral and anticancer drug candidates.
• Agrochemical Synthesis: Used as a building block for developing new herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a monomer or functional unit in the development of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology Probes: Utilized in the creation of labeled compounds and molecular probes for biochemical and diagnostic research due to its reactive ethynyl group.
• Academic & Industrial R&D: A valuable reagent for method development and exploring new reaction pathways in synthetic organic chemistry laboratories.
• Ligand Synthesis: Acts as a precursor for constructing complex ligands used in catalysis and coordination chemistry.

Basic Information

Product Name	Pyrimidine, 4-Ethynyl-2,6-Dimethyl- (9Ci)
CAS No.	86521-00-8
Molecular Formula	C8H8N2
Molecular Weight	132.16 g/mol
Synonyms	4-Ethynyl-2,6-dimethylpyrimidine; 2,6-Dimethyl-4-ethynylpyrimidine; 4-Ethynyl-2,6-lutidine; 86521-00-8; 4-Ethynyl-2,6-dimethylpyridine (incorrect but common misnomer); 2,6-Dimethyl-4-ethynyl-1,3-diazine
EINECS	Contact for details

Quality Control

Our Pyrimidine, 4-Ethynyl-2,6-Dimethyl- is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles. We support cGMP and ISO compliant manufacturing for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.