Description

1-Piperazinebutanol, 4-(8-Chloro-10,11-Dihydrodibenzo(B,F)Thiepin-10-Y L)-α-Methyl-, (Z)-2-Butenedioate (1:2) is a high-purity, non-racemic pharmaceutical intermediate of significant commercial importance. This compound is critical for the synthesis of advanced active pharmaceutical ingredients (APIs), particularly in the development of psychotropic and neuroactive drugs. It is primarily sought by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in the production of complex therapeutic agents.

Application

• Key Intermediate in API Synthesis: Serves as a crucial building block for the manufacture of specific psychotropic and neuroleptic pharmaceutical compounds.
• Pharmaceutical R&D: Used in medicinal chemistry research for the development and optimization of new drug candidates targeting the central nervous system.
• Fine Chemical Production: Employed in multi-step organic synthesis processes to create complex molecular architectures with high stereochemical purity.
• Reference Standard: Can be utilized as an analytical standard for quality control and regulatory compliance testing in pharmaceutical manufacturing.

Basic Information

Item	Details
Product Name	1-Piperazinebutanol, 4-(8-Chloro-10,11-Dihydrodibenzo(B,F)Thiepin-10-Y L)-α-Methyl-, (Z)-2-Butenedioate (1:2)
CAS No.	86499-16-3
Molecular Formula	C25H29ClN2O5S
Molecular Weight	505.03 g/mol
Synonyms	Zotepine Fumarate; Zotepine Hemifumarate; (Z)-2-Butenedioic acid, compd. with 4-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-1-methylpiperazine-1-butanol (2:1); 1-Piperazinebutanol, 4-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-1-methyl-, (2Z)-2-butenedioate (2:1); Zotepine Fumarate Salt; 4-(8-Chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-1-methylpiperazine-1-butanol fumarate (2:1)
EINECS	Contact for details

Quality Control

Our 1-Piperazinebutanol, 4-(8-Chloro-10,11-Dihydrodibenzo(B,F)Thiepin-10-Y L)-α-Methyl-, (Z)-2-Butenedioate (1:2) is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC for assay and chiral purity, to ensure it meets the high standards required for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.