Description

Geographutoxin II is a naturally occurring diterpenoid alkaloid isolated from Geographica-genus fungi and structurally characterized by a complex polycyclic framework with potent biological activity. It serves as a critical reference standard and pharmacological probe for neuroscience and toxicology research due to its selective modulation of voltage-gated sodium channels. This compound is primarily utilized by academic laboratories, contract research organizations (CROs), and pharmaceutical R&D teams engaged in ion channel drug discovery, neuropharmacology, and mechanistic toxicology studies. Geographutoxin Ii CAS NO 86414-29-1 is supplied under stringent quality controls to ensure batch-to-batch consistency and structural fidelity required for high-sensitivity assays.

Application

• Primary reference standard for HPLC and LC-MS/MS method validation in neurotoxin analysis
• Tool compound for electrophysiological studies of neuronal excitability and sodium channel kinetics
• Lead structure in medicinal chemistry programs targeting analgesic or anticonvulsant agents
• Positive control in cytotoxicity and neurotoxicity screening assays (e.g., SH-SY5Y, primary cortical neurons)
• Calibration material for quantitative bioanalysis in preclinical ADME/PK studies
• Research reagent in studies of neurodegenerative disease mechanisms involving ion channel dysregulation

Basic Information

Product Name	Geographutoxin II
CAS No.	86414-29-1
Molecular Formula	C33H47NO8
Molecular Weight	585.73 g/mol
Synonyms	Geographutoxin II; Geographotoxin II; 14-Deacetylgeographutoxin II; NSC 632191; Toxin G-II; Diterpenoid alkaloid G-II; C33H47NO8; Geographutoxin-2
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for identity (by HPLC retention time matching and IR spectroscopy), purity (≥98.5% by HPLC-UV), and absence of critical impurities (residual solvents, heavy metals, and microbial contamination). Testing adheres to ACS Reagent Grade and EP 10.0 guidelines where applicable, supporting regulatory submissions and GLP-compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8°C under inert atmosphere (argon or nitrogen) to prevent degradation. Due to its hygroscopic nature, maintain low-humidity conditions (<30% RH) and minimize exposure to ambient air during handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches certified reference standard
Assay (HPLC-UV)	≥98.5%
Related Substances	≤1.0% total impurities (single ≤0.3%)
Residual Solvents	Meets ICH Q3C limits
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.