Description

Calcitonin, Human, Des-Phe(16)- is a synthetic analogue of the human calcitonin hormone, specifically engineered for enhanced stability and research utility. This peptide is of critical importance for its role in studying calcium metabolism and bone physiology, offering a valuable tool for pharmaceutical development and biochemical research. It is primarily needed by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in metabolic disorder research, osteoporosis studies, and peptide-based therapeutic discovery.

Application

• Biomedical Research: A key reagent for in vitro and in vivo studies on calcium homeostasis, bone resorption, and renal calcium handling.
• Pharmaceutical R&D: Used as a reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel calcitonin-based therapies.
• Metabolic Studies: Employed to investigate disorders related to calcium and bone metabolism, such as Paget's disease and hypercalcemia.
• Analytical Standard: Serves as a high-purity calibrant for HPLC, LC-MS, and other analytical methods in quality control laboratories.
• Peptide Chemistry: Used as a model compound for studying peptide stability, structure-activity relationships (SAR), and formulation science.

Basic Information

Product Name	Calcitonin, Human, Des-Phe(16)-
CAS No.	86370-01-6
Molecular Formula	C₁₄₅H₂₄₀N₄₄O₄₇S₂
Molecular Weight	3367.8 g/mol
Synonyms	Des-Phenylalanine(16)-Human Calcitonin; hCT(1-32), Des-Phe16; Human Calcitonin (Des-Phe16); Calcitonin Human (Des-Phe16); Salmon Calcitonin Analog; [Des-Phe¹⁶]-Calcitonin; Cibacalcin Analog; Peptide Sequence: Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH₂ (Disulfide bridge: 1-7)
EINECS	Contact for details

Quality Control

Our Calcitonin, Human, Des-Phe(16)- is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and peptide content, mass spectrometry for identity confirmation, and tests for related substances and residual solvents. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to ensure full traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Single Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%
Amino Acid Analysis	Within ±10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.