Description

Misonidazole-Glutathione Conjugate is a specialized biochemical research compound formed by linking the radiosensitizer misonidazole to the endogenous antioxidant glutathione. This conjugate is of significant interest for studying the mechanisms of chemosensitization, redox biology, and cellular detoxification pathways under hypoxic conditions. It serves as a critical tool for researchers in oncology, radiation biology, and pharmaceutical development, particularly for investigating drug metabolism and overcoming tumor resistance.

Application

• Biochemical Research: A key reagent for studying the interaction between nitroimidazole-based radiosensitizers and cellular thiol systems.
• Oncology & Radiation Biology: Used to investigate mechanisms of chemosensitization and the role of glutathione in modulating the efficacy and toxicity of nitroimidazole drugs in hypoxic tumor environments.
• Metabolic Pathway Analysis: Employed as a model substrate to explore enzymatic and non-enzymatic conjugation pathways relevant to drug metabolism and detoxification.
• Redox & Oxidative Stress Studies: Useful for probing cellular redox states and the impact of thiol-disulfide balance on drug activity and cellular response to radiation.
• Pharmaceutical Development: Acts as a reference standard or intermediate in the development and analytical validation of novel radiosensitizing or chemosensitizing agents.
• Toxicology Research: Applied in studies assessing the metabolic fate and potential adduct formation of nitroaromatic compounds.

Basic Information

Product Name	Misonidazole-Glutathione Conjugate
CAS No.	86356-71-0
Molecular Formula	C19H30N8O9S
Molecular Weight	546.55 g/mol
Synonyms	1-(2-Nitro-1-imidazolyl)-3-[N-(γ-L-glutamyl-L-cysteinyl)glycyl]oxy]-2-propanol; Misonidazole-GSH Conjugate; Glutathione-Misonidazole Adduct; NSC 351178; γ-Glu-Cys-Gly-Misonidazole Conjugate; 2-Propanol, 1-(2-nitro-1H-imidazol-1-yl)-3-[[N-(N-L-γ-glutamyl-L-cysteinyl)glycyl]oxy]-, (2R)-
EINECS	Contact for details

Quality Control

Our Misonidazole-Glutathione Conjugate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC for purity assessment and spectroscopic methods (NMR, MS) for structural confirmation, to ensure identity and consistency. Certificates of Analysis (COA) with detailed chromatographic and spectral data are provided to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.