Description

Fmoc-D-Tryptophan CAS NO 86123-11-7 is a protected, enantiomerically pure derivative of the essential amino acid tryptophan, featuring the fluorenylmethyloxycarbonyl (Fmoc) protecting group on the α-amino function. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptides and proteins. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, biochemical probes, and novel biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, stepwise construction of custom peptide sequences.
• Pharmaceutical Research: Synthesis of peptide-based drug candidates, hormones, and diagnostic agents where the D-tryptophan configuration is required for stability or biological activity.
• Bioconjugation & Probe Development: Incorporation of the unique indole side chain for fluorescence studies, protein labeling, or as a site for further chemical modification.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Biochemical Research: Fundamental studies on protein structure-function relationships, enzyme substrates, and receptor-ligand interactions.
• Production of Protected Peptide Fragments: For use in fragment condensation or native chemical ligation strategies.

Basic Information

Product Name	Fmoc-D-Tryptophan
CAS No.	86123-11-7
Molecular Formula	C26H22N2O4
Molecular Weight	426.47 g/mol
Synonyms	Fmoc-D-Trp-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-tryptophan; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoic acid; D-Fmoc-Tryptophan; Fmoc-D-Try-OH; N-Fmoc-D-tryptophan; (R)-2-(Fmoc-amino)-3-(1H-indol-3-yl)propionic acid
EINECS	Contact for details

Quality Control

Our Fmoc-D-Tryptophan is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive applications like peptide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to relevant industry standards and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.