Description

n-Fmoc-L-Threonine Pentafluorophenyl Ester is a high-purity, activated amino acid derivative widely used in solid-phase peptide synthesis (SPPS). This compound serves as a crucial building block, enabling the efficient and selective incorporation of threonine residues under mild conditions. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected, pentafluorophenyl (Pfp) activated ester for the controlled coupling of L-threonine.
• Pharmaceutical Intermediate: For the research and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Used in the site-specific modification of proteins, antibodies, and other biomolecules to create conjugates for targeted therapies.
• Combinatorial Chemistry: A valuable reagent in library synthesis for high-throughput screening and drug discovery programs.
• Glycopeptide Synthesis: Facilitates the synthesis of peptides containing glycosylated threonine residues.
• Academic & Industrial R&D: A fundamental reagent for synthetic chemistry and biochemistry research in both university and corporate laboratories.

Basic Information

Product Name	n-Fmoc-L-Threonine Pentafluorophenyl Ester
CAS No.	86061-06-5
Molecular Formula	C26H20F5NO6
Molecular Weight	537.44 g/mol
Synonyms	Fmoc-Thr(Pfp)-OH; Fmoc-L-Threonine Pentafluorophenyl Ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-threonine Pentafluorophenyl Ester; (2S,3R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-hydroxybutanoic acid 2,3,4,5,6-pentafluorophenyl ester; Fmoc-Thr-O-Pfp; Fmoc-Threonine(Pfp)-OH; Fmoc-Thr(OPfp)-OH; Fmoc-Threonine Pentafluorophenyl Ester
EINECS	Contact for details

Quality Control

Our n-Fmoc-L-Threonine Pentafluorophenyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.