Description

n-Fmoc-L-Serine Pentafluorophenyl Ester is a highly reactive, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound matters because it provides a convenient and efficient method for the controlled incorporation of serine into peptide chains, minimizing side reactions and improving yield. It is primarily needed by pharmaceutical R&D teams, biotech companies, and CROs engaged in the development of therapeutic peptides, peptidomimetics, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the automated, sequential assembly of peptides, particularly for introducing serine residues.
• Therapeutic Peptide Development: For the research and production of peptide-based drugs targeting metabolic disorders, oncology, and infectious diseases.
• Peptidomimetic & Conjugate Synthesis: Enables the creation of modified peptides with enhanced stability, bioavailability, or targeting properties.
• Biochemical Research: Used in academic and industrial labs to synthesize custom peptide sequences for structure-activity relationship (SAR) studies and protein-protein interaction analysis.
• Labeled Peptide Production: Facilitates the synthesis of peptides containing isotopically labeled or fluorescently tagged serine for diagnostic and imaging applications.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: Serves as a precursor in the synthesis of specialized linkers that connect cytotoxic drugs to monoclonal antibodies.

Basic Information

Product Name	n-Fmoc-L-Serine Pentafluorophenyl Ester
CAS No.	86061-05-4
Molecular Formula	C24H16F5NO6
Molecular Weight	509.38 g/mol
Synonyms	Fmoc-Ser-OPh(CF3)2; Fmoc-L-Serine Pentafluorophenyl Ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-serine 2,3,4,5,6-pentafluorophenyl ester; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-hydroxypropanoic acid 2,3,4,5,6-pentafluorophenyl ester; Fmoc-Ser(Pfp)-OH; Fmoc-Ser-OPfp; N-α-Fmoc-L-serine pentafluorophenyl ester; Pentafluorophenyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serinate
EINECS	Contact for details

Quality Control

Our n-Fmoc-L-Serine Pentafluorophenyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) with detailed specifications are provided to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For long-term storage under inert atmosphere, contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]D20	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.