Description

Fmoc-Asp(Obzl)-Opfp CAS NO 86061-03-2 is a specialized, high-purity amino acid derivative used as a key building block in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers who require precise control over peptide chain assembly, particularly for introducing aspartic acid with a protected side chain. It is an essential reagent for pharmaceutical R&D, biotechnology, and academic laboratories developing therapeutic peptides, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid activated with the pentafluorophenyl (Opfp) ester, it is designed for efficient, racemization-free coupling in automated and manual peptide synthesis.
• Pharmaceutical Intermediate: Used in the research and production of peptide-based active pharmaceutical ingredients (APIs) and novel drug candidates.
• Bioconjugation: Serves as a precursor for creating peptide-protein conjugates, antibody-drug conjugates (ADCs), and other labeled biomolecules.
• Combinatorial Chemistry: A valuable building block for generating diverse peptide libraries for high-throughput screening in drug discovery.
• Biochemical Research: Employed in studying enzyme-substrate interactions, protein folding, and structure-activity relationships (SAR).
• Custom Peptide Service: A fundamental raw material for contract research and manufacturing organizations (CROs/CMOs) offering custom peptide synthesis services.

Basic Information

Product Name	Fmoc-Asp(Obzl)-Opfp
CAS No.	86061-03-2
Molecular Formula	C32H24F5NO6
Molecular Weight	613.53 g/mol
Synonyms	Fmoc-L-aspartic acid β-benzyl ester pentafluorophenyl ester; Fmoc-Asp(OBzl)-OPfp; N-(9-Fluorenylmethoxycarbonyl)-L-aspartic acid 4-benzyl ester 1-(pentafluorophenyl) ester; Fmoc-Asp-OBzl-OPfp; Fmoc-Asp(OBzl)-OPfp ester; Fmoc-Asp(OBn)-OPfp; Fmoc-L-Asp(OBzl)-OPfp; Nα-Fmoc-L-aspartic acid β-benzyl ester α-pentafluorophenyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Asp(Obzl)-Opfp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices and can provide material traceable to relevant standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.