Description

Fmoc-Asp(Otbu)-Opfp is a high-purity, protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the efficient and selective construction of complex peptides, offering superior coupling efficiency and minimal racemization. It is an essential reagent for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the automated and manual synthesis of peptides, particularly those containing aspartic acid.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Serves as a reagent for the site-specific modification of proteins, antibodies, and other biomolecules.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Biochemical Research: A fundamental tool for studying protein structure-function relationships, enzyme substrates, and receptor ligands.
• Production of Custom Peptides: Essential for contract research organizations (CROs) and CDMOs producing bespoke peptides for clients.

Basic Information

Product Name	Fmoc-Asp(Otbu)-Opfp
CAS No.	86061-01-0
Molecular Formula	C25H24F5NO6
Molecular Weight	529.46 g/mol
Synonyms	Fmoc-L-aspartic acid 4-tert-butyl ester pentafluorophenyl ester; N-(9-Fluorenylmethoxycarbonyl)-L-aspartic acid β-tert-butyl ester α-pentafluorophenyl ester; Fmoc-Asp(OtBu)-OPfp; Fmoc-Asp(OtBu)-OPfp ester; Fmoc-Asp(OtBu)-OPfp; Fmoc-L-Asp(OtBu)-OPfp; Nα-Fmoc-L-aspartic acid 4-tert-butyl ester pentafluorophenyl ester; Fmoc-Aspartyl(OtBu)-OPfp
EINECS	Contact for details

Quality Control

Our Fmoc-Asp(Otbu)-Opfp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and production applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices and can provide material traceable to relevant standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.