Description

Fmoc-Gln-Opfp is a specialized, activated amino acid derivative used in solid-phase peptide synthesis (SPPS). This compound matters as a key building block for the efficient and high-purity incorporation of glutamine into peptide chains, offering significant advantages in yield and reduced racemization. It is primarily needed by research institutions, pharmaceutical developers, and CROs/CMOs engaged in the production of therapeutic peptides, peptide hormones, and biochemical research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester (Opfp), it serves as a crucial reagent for the rapid and efficient coupling of Fmoc-protected glutamine.
• Therapeutic Peptide Development: Used in the research and production of peptide-based pharmaceuticals, including hormone analogs and antimicrobial peptides.
• Combinatorial Chemistry: A valuable component in libraries for drug discovery and structure-activity relationship (SAR) studies.
• Bioconjugation: Can be utilized for the site-specific labeling or modification of peptides and proteins.
• Academic & Industrial Research: A standard reagent in laboratories focused on peptide chemistry, biochemistry, and molecular biology.
• Custom Peptide Service Providers: Essential inventory for CROs and CMOs offering bespoke peptide synthesis services.

Basic Information

Product Name	Fmoc-Gln-Opfp
CAS No.	86061-00-9
Molecular Formula	C₂₆H₂₀F₅NO₆
Molecular Weight	537.44 g/mol
Synonyms	Fmoc-Glutamine-OPfp; Fmoc-Gln-OPfp; N-(9-Fluorenylmethoxycarbonyl)-L-glutamine pentafluorophenyl ester; Fmoc-L-glutamine pentafluorophenyl ester; Nα-Fmoc-L-glutamine pentafluorophenyl ester; Fmoc-Gln-OPfp ester; Fmoc-Gln(OtBu)-OPfp (common precursor variant); L-Glutamine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluoro-6-(trifluoromethyl)hexane-1,3,5-triyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Gln-Opfp is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity. A Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0% (Area Percent)
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.