Description

Fmoc-Lys(Boc)-Opfp is a protected amino acid derivative widely used as a key building block in solid-phase peptide synthesis (SPPS). This compound is essential for the efficient and selective introduction of lysine residues with orthogonal side-chain protection, enabling the synthesis of complex peptides and bioconjugates. It is a critical raw material for pharmaceutical R&D, biotechnology, and academic research focused on developing novel therapeutic peptides, protein mimetics, and diagnostic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary reagent for the controlled incorporation of lysine into peptide chains using Fmoc chemistry.
• Pharmaceutical Intermediates: Key building block in the production of active pharmaceutical ingredients (APIs) for peptide-based therapeutics.
• Bioconjugation: Used to create peptide tags, linkers, or functionalized peptides for coupling with proteins, antibodies, or other biomolecules.
• Research & Development: Essential tool in academic and industrial labs for exploring new peptide structures, drug candidates, and biochemical probes.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening and drug discovery.
• Glycopeptide Synthesis: Serves as a precursor for the synthesis of modified peptides, such as glycopeptides, where specific side-chain functionalization is required.

Basic Information

Product Name	Fmoc-Lys(Boc)-Opfp
CAS No.	86060-98-2
Molecular Formula	C₃₂H₃₁F₅N₂O₇
Molecular Weight	650.60 g/mol
Synonyms	Fmoc-Lys(Boc)-OPfp; N-α-Fmoc-N-ε-Boc-L-lysine pentafluorophenyl ester; Fmoc-Lys(Boc)-O-Pfp; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-[(1,1-dimethylethoxy)carbonyl]-L-lysine 2,3,4,5,6-pentafluorophenyl ester; Fmoc-Lys(Boc)-OPfp ester; Fmoc-Lys(Boc)-OPfp active ester; Fmoc-N-ε-Boc-L-lysine pentafluorophenyl ester; Fmoc-Lys(Boc)-OPfp Pentafluorophenyl Ester
EINECS	Contact for details

Quality Control

Our Fmoc-Lys(Boc)-Opfp is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive applications like peptide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems support compliance with global regulatory requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.