Description

Fmoc-Met-Opfp CAS NO 86060-94-8 is a high-purity, protected amino acid derivative specifically designed for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise and efficient coupling of methionine residues while maintaining orthogonal protection strategies. It is an essential building block for pharmaceutical R&D, particularly in the development of therapeutic peptides, APIs, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected methionine derivative activated with pentafluorophenyl (OPfp) ester for efficient coupling.
• Pharmaceutical Research & Development: For the synthesis of peptide-based drug candidates, active pharmaceutical ingredients (APIs), and investigative new compounds.
• Bioconjugation and Labeling: Used in the site-specific modification of peptides and proteins for diagnostic or therapeutic purposes.
• Combinatorial Chemistry: A valuable reagent in library synthesis for high-throughput screening and drug discovery platforms.
• Academic & Institutional Research: Essential for biochemical and structural biology studies involving synthetic peptides.
• Custom Peptide Service Providers: A fundamental raw material for CROs and CDMOs offering bespoke peptide synthesis services.

Basic Information

Product Name	Fmoc-Met-Opfp
CAS No.	86060-94-8
Molecular Formula	C₂₆H₂₀F₅NO₅S
Molecular Weight	553.50 g/mol
Synonyms	Fmoc-Methionine pentafluorophenyl ester; N-(9-Fluorenylmethoxycarbonyl)-L-methionine pentafluorophenyl ester; Fmoc-L-methionine OPfp ester; Fmoc-Met-OPfp; Nα-Fmoc-L-methionine pentafluorophenyl ester; (2,3,4,5,6-Pentafluorophenyl) N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methioninate; Fmoc-Met-OPh(2,3,4,5,6-F5)
EINECS	Contact for details

Quality Control

Our Fmoc-Met-Opfp is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements of peptide synthesis. Certificates of Analysis (COA) with full traceability are provided to guarantee reproducible performance and supply reliability for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation	-25.0° to -30.0° (c=1, DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.