Description

Fmoc-Ile-Opfp is a highly reactive, protected amino acid derivative used as a key building block in solid-phase peptide synthesis (SPPS). Its value lies in the pentafluorophenyl (Opfp) ester group, which acts as an efficient leaving group, enabling rapid and high-yielding coupling reactions under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise and efficient construction of complex peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical reagent for the efficient, stepwise assembly of peptide chains on resin supports.
• Solution-Phase Peptide Synthesis: Used in classical solution methods for coupling amino acid segments.
• Production of Pharmaceutical Intermediates: Synthesis of active pharmaceutical ingredients (APIs) and drug candidates with peptide backbones.
• Bioconjugation: Facilitating the attachment of peptides to other molecules, such as proteins, polymers, or surfaces, for drug delivery and diagnostic applications.
• Research & Development: A staple tool in academic and industrial R&D labs for exploring new peptide-based therapeutics, hormones, and enzyme inhibitors.
• Synthesis of Modified Peptides: Incorporation of isoleucine residues with orthogonal Fmoc protection for synthesizing complex or labeled peptides.

Basic Information

Product Name	Fmoc-Ile-Opfp
CAS No.	86060-89-1
Molecular Formula	C26H20F5NO5
Molecular Weight	521.44 g/mol
Synonyms	Fmoc-L-isoleucine pentafluorophenyl ester; N-(9-Fluorenylmethoxycarbonyl)-L-isoleucine pentafluorophenyl ester; Fmoc-Ile-OPfp; Fmoc-Ile-OPh(CF3)2; (9H-Fluoren-9-yl)methyl (2S,3S)-2-(((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methylpentanoate (pentafluorophenyl ester analog); N-α-Fmoc-L-isoleucine pentafluorophenyl ester; Fmoc-Ile-O-Pfp; Fmoc-Isoleucine Opfp Ester
EINECS	Contact for details

Quality Control

Our Fmoc-Ile-Opfp is manufactured under strict quality protocols to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.