Description

Fmoc-Val-Opfp CAS NO 86060-87-9 is a specialized amino acid derivative, specifically an N-Fmoc-protected valine activated with pentafluorophenyl ester (Opfp). This compound is a critical building block in solid-phase peptide synthesis (SPPS), offering high reactivity and selectivity for efficient amide bond formation. It is primarily utilized by research scientists and process chemists in pharmaceutical R&D, biotechnology, and fine chemical synthesis for the production of peptides, peptidomimetics, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester, it is a key reagent for the efficient and racemization-free incorporation of valine into growing peptide chains.
• Solution-Phase Peptide Synthesis: Used in classical solution-phase methods for the synthesis of short peptides and peptide fragments.
• Pharmaceutical Intermediate: Serves as a crucial intermediate in the research and development of therapeutic peptides and peptide-based drugs.
• Bioconjugation: Employed in the site-specific labeling and modification of proteins, antibodies, and other biomolecules.
• Combinatorial Chemistry: Used in the generation of diverse peptide libraries for drug discovery and screening applications.
• Academic & Industrial Research: A fundamental tool in biochemistry and medicinal chemistry laboratories for studying protein structure-function relationships.

Basic Information

Product Name	Fmoc-Val-Opfp
CAS No.	86060-87-9
Molecular Formula	C26H20F5NO5
Molecular Weight	521.44 g/mol
Synonyms	Fmoc-Val-OPfp; N-(9-Fluorenylmethoxycarbonyl)-L-valine pentafluorophenyl ester; Fmoc-L-valine pentafluorophenyl ester; Fmoc-Valine-OPfp ester; N-α-Fmoc-L-valine pentafluorophenyl ester; (9H-Fluoren-9-yl)methyl (2S)-2-[(2-methylpropanoyl)oxy]-3-methylbutanoate (Pentafluorophenyl ester analog); Fmoc-Val-OPfp Ester; Fmoc-Val-Opfp CAS NO 86060-87-9
EINECS	Contact for details

Quality Control

Our Fmoc-Val-Opfp is manufactured under strict quality control protocols to ensure high chemical purity and consistent performance in sensitive synthetic applications. Each batch is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.